Cheap Flights from St. Louis to Panama City
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Flights from St. Louis to Panama City
Find cheap flights from St. Louis to Panama City
We've found these cheap flights for you. You can book one-way or round-trip flight tickets.
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STL 12:515h 13m1 stopsECP 18:04St. Louis - Panama City | Tue, Apr 15 | Delta Air Lines
ECP 06:005h 41m1 stopsSTL 11:41Panama City - St. Louis | Sat, Apr 19 | Delta Air LinesUS$320 US$37014% OFF14% OFFUS$370 US$320 -
STL 06:003h 49m1 stopsECP 09:49St. Louis - Panama City | Tue, May 20 | Delta Air Lines
ECP 13:596h 40m1 stopsSTL 20:39Panama City - St. Louis | Tue, May 27 | Delta Air LinesUS$321 US$37013% OFF13% OFFUS$370 US$321
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STL 06:003h 49m1 stopsECP 09:49St. Louis - Panama City | Wed, May 28 | Delta Air Lines
ECP 13:596h 40m1 stopsSTL 20:39Panama City - St. Louis | Wed, Jun 4 | Delta Air LinesUS$321 US$37013% OFF13% OFFUS$370 US$321
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STL 13:055h1 stopsECP 18:05St. Louis - Panama City | Sat, Apr 12 | Delta Air Lines
ECP 07:304h 15m1 stopsSTL 11:45Panama City - St. Louis | Wed, Apr 16 | Delta Air LinesUS$32512% OFFUS$370 US$325
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STL 06:003h 49m1 stopsECP 09:49St. Louis - Panama City | Mon, May 12 | Delta Air Lines
ECP 16:314h 8m1 stopsSTL 20:39Panama City - St. Louis | Mon, May 19 | Delta Air LinesUS$32612% OFFUS$370 US$326
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STL 16:003h 35m1 stopsECP 19:35St. Louis - Panama City | Wed, Apr 16 | Delta Air Lines
ECP 19:054h 33m1 stopsSTL 23:38Panama City - St. Louis | Tue, Apr 22 | Delta Air LinesUS$33011% OFFUS$370 US$330
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STL 19:123h 53m1 stopsECP 23:05St. Louis - Panama City | Fri, Apr 11 | Delta Air Lines
ECP 06:005h 45m1 stopsSTL 11:45Panama City - St. Louis | Thu, Apr 17 | Delta Air LinesUS$33210% OFFUS$370 US$332
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STL 19:014h 2m1 stopsECP 23:03St. Louis - Panama City | Fri, May 2 | Delta Air Lines
ECP 18:384h 58m1 stopsSTL 23:36Panama City - St. Louis | Mon, May 5 | Delta Air LinesUS$33310% OFFUS$370 US$333
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STL 06:004h 14m1 stopsECP 10:14St. Louis - Panama City | Sun, Apr 20 | Delta Air Lines
ECP 06:003h 36m1 stopsSTL 09:36Panama City - St. Louis | Fri, Apr 25 | Delta Air LinesUS$33510% OFFUS$370 US$335
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STL 16:436h 22m1 stopsECP 23:05St. Louis - Panama City | Fri, Apr 4 | Delta Air Lines
ECP 18:504h 39m1 stopsSTL 23:29Panama City - St. Louis | Mon, Apr 7 | Delta Air LinesUS$3379% OFFUS$370 US$337
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STL 13:0017h 25m1 stopsECP Invalid DateSt. Louis - Panama City | Wed, Apr 2 | Normal Airline
ECP 15:006hNonstopSTL 16:00Panama City - St. Louis | Fri, Apr 4 | Normal AirlineFind More FlightsFind More Flights
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STL 17:324h 21m1 stopsECP 21:53St. Louis - Panama City | Tue, Apr 22 | Delta Air LinesUS$112 US$22249% OFF49% OFFUS$222 US$112
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STL 16:115h 42m1 stopsECP 21:53St. Louis - Panama City | Tue, Apr 15 | Delta Air LinesUS$118 US$22247% OFF47% OFFUS$222 US$118
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STL 06:306h 55m1 stopsECP 13:25St. Louis - Panama City | Tue, Apr 22 | United AirlinesUS$144 US$22235% OFF35% OFFUS$222 US$144 -
STL 15:444h 53m1 stopsECP 20:37St. Louis - Panama City | Tue, Apr 22 | American AirlinesUS$14833% OFFUS$222 US$148 -
STL 06:004h 14m1 stopsECP 10:14St. Louis - Panama City | Sun, Apr 20 | Delta Air LinesUS$15530% OFFUS$222 US$155
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STL 19:123h 53m1 stopsECP 23:05St. Louis - Panama City | Sun, Apr 13 | Delta Air LinesUS$17621% OFFUS$222 US$176
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STL 06:156h 10m1 stopsECP 12:25St. Louis - Panama City | Sat, May 17 | United AirlinesUS$18118% OFFUS$222 US$181
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STL 06:156h 25m1 stopsECP 12:40St. Louis - Panama City | Sun, Apr 20 | United AirlinesUS$19014% OFFUS$222 US$190
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STL 05:004h 28m1 stopsECP 09:28St. Louis - Panama City | Sun, Apr 20 | American AirlinesUS$19512% OFFUS$222 US$195
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STL 06:003h 49m1 stopsECP 09:49St. Louis - Panama City | Fri, May 16 | Delta Air LinesUS$2029% OFFUS$222 US$202
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STL 13:0017h 25m1 stopsECP Invalid DateSt. Louis - Panama City | Wed, Apr 2 | Normal AirlineFind More FlightsFind More Flights
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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.
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Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Frequently Asked Questions
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When are flight tickets from St. Louis (STL) to Panama City (ECP) the cheapest?
Airlines adjust prices for flights from St. Louis to Panama City based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays. -
How much do flights from St. Louis (STL) to Panama City (ECP) cost?
According to Trip.com's data, the lowest price is around $482. -
How long does it take to fly from St. Louis (STL) to Panama City (ECP) and what is the distance?
It takes around 1 hour 47 minutes to fly from St. Louis (STL) to Panama City (ECP). -
What are the most popular airlines that fly from St. Louis (STL) to Panama City (ECP)?
Airlines with flights from St. Louis (STL) to Panama City (ECP): Southwest Airlines.
How to find a cheap flight from St. Louis to Panama City
Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from St. Louis to Panama City. Book your flights at the right time and save more.
Being flexible with your dates to get the cheapest St. Louis to Panama City ticket.
Tap "Date" on flight search bar to scan through the calender for St. Louis to Panama City airfare over next 6 months in 2025. If you would like to fly in next 3 months, it seems the cheapest date is on Tue, Apr 22 at US$112 for one-way flights.
Compare cheap St. Louis to Panama City flight deals from over hundreds of airlines.
Our extensive search allows you to compare prices from over 500 airlines to choose the cheapest flight tickets from St. Louis to Panama City. The cheapest airline operating is Delta Air Lines.
Set up a Price Alert
By setting up a Price Alert for your St. Louis to Panama City route, you can easily track the price of your airline tickets from St. Louis to Panama City without manually checking every day.
Don't miss cheap St. Louis to Panama City flight deals and promo codes.
You can always get the latest deals through Trip.com Deals and Promo Codes for cheap flights for cheap flights. If registering a free membership, you can receive more deals for your flights.
Book early or wait unitl the last minute.
It's always better to book early. Flight tickets tend to be the cheapest when they are first released, normally about a year before the departure date. So, check online as soon as the flights you want become available. If you miss the cheapest time, you can still find lower-priced tickets as the flight date approaches.
Search for flights on the go.
To get the best flight booking experience on the go, download Trip.com free app and search for cheap flight tickets from St. Louis to Panama City to get exclusive deals for you.
St. Louis to Panama City Flight Information
| Cheapest one-way flight price | $112 |
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| Off-season for travel | March |
| Peak season for travel | January |
| Flight distance | 1,025.63 km |
| Average flight time | 1 hour 47 minutes |
| Popular airline | Delta Air Lines |
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