Find cheap one-way flights from Medellin to Santiago del Estero starting at US$1,136.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Medellin to Santiago del Estero?

We monitor flight fares to help you find the best deals effortlessly

Cheapest flights

From price

23 30
Apr

30 6
6 13
13 20
20 27
May

27 4
4 11
11 18
18 25
Jun

25 1
1 8
8 15

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

When are flight tickets from Medellin (MDE) to Santiago del Estero (SDE) the cheapest?

Airlines adjust prices for flights from Medellin to Santiago del Estero based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
How much do flights from Medellin (MDE) to Santiago del Estero (SDE) cost?

According to Trip.com's data, the lowest price is around $999.
What is the transportation method from the main airport to downtown in Santiago del Estero?
- The distance from Santiago Del Estero Airport to downtown is about 4 km. It takes about 20 minutes by taxi.

How to find a cheap flight from Medellin to Santiago del Estero

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Medellin to Santiago del Estero. Book your flights at the right time and save more.

Being flexible with your dates to get the cheapest Medellin to Santiago del Estero ticket.

Tap "Date" on flight search bar to scan through the calender for Medellin to Santiago del Estero airfare over next 6 months in 2025.

Compare cheap Medellin to Santiago del Estero flight deals from over hundreds of airlines.

Our extensive search allows you to compare prices from over 500 airlines to choose the cheapest flight tickets from Medellin to Santiago del Estero.

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Book early or wait unitl the last minute.

It's always better to book early. Flight tickets tend to be the cheapest when they are first released, normally about a year before the departure date. So, check online as soon as the flights you want become available. If you miss the cheapest time, you can still find lower-priced tickets as the flight date approaches.

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