App
Customer Support
USD
Find Bookings
Trip.com
>
Flights
>
Flights to Argentina
>
Flights to Santiago del Estero
>
Madrid to Santiago del Estero flight
>
Madrid to Santiago Del Estero Airport flight
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Cheap Flights from Madrid to Santiago Del Estero Airport

  • One way
  • Round-trip
      • MAD10:55
        27h 5m
        1 stop
        SDE09:00
        Madrid - Santiago del Estero|Mon, May 5|Aerolineas Argentinas
        US$588US$1,184
        50% OFF
        50% OFF
        US$1,184US$588

        Choose Aerolineas Argentinas flights from Madrid to Santiago del Estero.The one-way connecting flight with Aerolineas Argentinas departs from Madrid Barajas Airport on Mon, May 5, arriving at Santiago Del Estero Airport.One-way Prices start from US$588 including taxes and charges.

      • MAD20:05
        30h 10m
        1 stop
        SDE21:15
        Madrid - Santiago del Estero|Sun, May 11|Aerolineas Argentinas
        US$602US$1,184
        49% OFF
        49% OFF
        US$1,184US$602

        Choose Aerolineas Argentinas flights from Madrid to Santiago del Estero.The one-way connecting flight with Aerolineas Argentinas departs from Madrid Barajas Airport on Sun, May 11, arriving at Santiago Del Estero Airport.One-way Prices start from US$602 including taxes and charges.

      • MAD10:55
        38h 40m
        1 stop
        SDE20:35
        Madrid - Santiago del Estero|Fri, Apr 11|Aerolineas Argentinas
        US$631US$1,184
        47% OFF
        47% OFF
        US$1,184US$631

        Choose Aerolineas Argentinas flights from Madrid to Santiago del Estero.The one-way connecting flight with Aerolineas Argentinas departs from Madrid Barajas Airport on Fri, Apr 11, arriving at Santiago Del Estero Airport.One-way Prices start from US$631 including taxes and charges.

      • MAD20:05
        25h 40m
        1 stop
        SDE16:45
        Madrid - Santiago del Estero|Tue, Apr 15|Aerolineas Argentinas
        US$710
        US$710

        Choose Aerolineas Argentinas flights from Madrid to Santiago del Estero.The one-way connecting flight with Aerolineas Argentinas departs from Madrid Barajas Airport on Tue, Apr 15, arriving at Santiago Del Estero Airport.One-way Prices start from US$710 including taxes and charges.

      • MAD08:45
        37h
        1 stop
        SDE16:45
        Madrid - Santiago del Estero|Tue, Apr 15|Iberia
        US$738
        US$738

        Choose Iberia flights from Madrid to Santiago del Estero.The one-way connecting flight with Iberia departs from Madrid Barajas Airport on Tue, Apr 15, arriving at Santiago Del Estero Airport.One-way Prices start from US$738 including taxes and charges.

      • MAD20:05
        30h
        1 stop
        SDE21:05
        Madrid - Santiago del Estero|Thu, May 22|Aerolineas Argentinas
        US$752
        US$752

        Choose Aerolineas Argentinas flights from Madrid to Santiago del Estero.The one-way connecting flight with Aerolineas Argentinas departs from Madrid Barajas Airport on Thu, May 22, arriving at Santiago Del Estero Airport.One-way Prices start from US$752 including taxes and charges.

      • MAD23:55
        21h 35m
        1 stop
        SDE16:30
        Madrid - Santiago del Estero|Thu, May 22|Air Europa
        US$773
        US$773

        Choose Air Europa flights from Madrid to Santiago del Estero.The one-way connecting flight with Air Europa departs from Madrid Barajas Airport on Thu, May 22, arriving at Santiago Del Estero Airport.One-way Prices start from US$773 including taxes and charges.

      • MAD23:55
        20h 45m
        1 stop
        SDE15:40
        Madrid - Santiago del Estero|Sun, May 11|Air Europa
        US$785
        US$785

        Choose Air Europa flights from Madrid to Santiago del Estero.The one-way connecting flight with Air Europa departs from Madrid Barajas Airport on Sun, May 11, arriving at Santiago Del Estero Airport.One-way Prices start from US$785 including taxes and charges.

      • MAD23:55
        21h 50m
        1 stop
        SDE16:45
        Madrid - Santiago del Estero|Tue, Apr 15|Air Europa
        US$787
        US$787

        Choose Air Europa flights from Madrid to Santiago del Estero.The one-way connecting flight with Air Europa departs from Madrid Barajas Airport on Tue, Apr 15, arriving at Santiago Del Estero Airport.One-way Prices start from US$787 including taxes and charges.

      • MAD08:45
        37h 25m
        1 stop
        SDE17:10
        Madrid - Santiago del Estero|Sun, Mar 30|Iberia
        US$801
        US$801

        Choose Iberia flights from Madrid to Santiago del Estero.The one-way connecting flight with Iberia departs from Madrid Barajas Airport on Sun, Mar 30, arriving at Santiago Del Estero Airport.One-way Prices start from US$801 including taxes and charges.

      • MAD1:00 PM
        3h 5m
        Nonstop
        SDE2:00 PM
        Madrid - Santiago del Estero|Fri, Apr 4|Aerolineas Argentinas
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

There are 1 airport(s) in Madrid. Discover the top routes now!

  • 2.63 km from downtown Madrid
    Madrid Barajas Airport
    Tickets From
    US$505

Flight Schedule from Madrid to Santiago Del Estero Airport

Flight info.
Departure
Arrival
Weekly Schedule

  1. IB271

    IBERIA

    11:45

    MAD

    11.0h

    17:45

    GRU

    SMTWTFS
    Search

  2. LA8138

    LATAM Airlines

    18:30

    GRU

    3.0h

    21:30

    AEP

    SMTWT-S

  3. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-

  4. IB269

    IBERIA

    12:10

    MAD

    10.6h

    17:45

    GIG

    -MT--F-
    Search

  5. AR1269

    Aerolineas Argentinas

    20:55

    GIG

    3.4h

    00:20

    AEP

    SM-WTF-

  6. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-

  7. AZ063

    ITA Airways

    18:05

    MAD

    2.4h

    20:30

    FCO

    SMTWTFS
    Search

  8. AZ680

    ITA Airways

    22:30

    FCO

    14.0h

    07:30

    EZE

    SMTWTFS

  9. FO5230

    Flybondi

    15:15

    AEP

    1.8h

    17:00

    SDE

    SMTWTF-

  10. AR1133

    Aerolineas Argentinas

    20:05

    MAD

    13.1h

    04:10

    EZE

    SMTWTFS
    Search

  11. AR1464

    Aerolineas Argentinas

    19:25

    AEP

    1.8h

    21:15

    SDE

    S--WT-S

  12. AR1133

    Aerolineas Argentinas

    20:05

    MAD

    13.1h

    04:10

    EZE

    SMTWTFS
    Search

  13. FO5230

    Flybondi

    15:15

    AEP

    1.8h

    17:00

    SDE

    SMTWTF-

  14. AR1133

    Aerolineas Argentinas

    20:05

    MAD

    13.1h

    04:10

    EZE

    SMTWTFS
    Search

  15. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-

  16. OB777

    Boliviana De Aviación

    21:00

    MAD

    11.5h

    02:30

    VVI

    ----T-S
    Search

  17. OB708

    Boliviana De Aviación

    10:00

    VVI

    2.9h

    13:55

    EZE

    SMTWTFS

  18. AR1464

    Aerolineas Argentinas

    19:25

    AEP

    1.8h

    21:15

    SDE

    S--WT-S

  19. CA897

    Air China

    22:15

    MAD

    10.8h

    05:05

    GRU

    S--W--S
    Search

  20. G37636

    Gol Linhas Aereas Inteligentes

    06:15

    GRU

    3.1h

    09:20

    AEP

    SMTW--S

  21. FO5230

    Flybondi

    15:15

    AEP

    1.8h

    17:00

    SDE

    SMTWTF-

  22. LA715

    LATAM Airlines

    23:45

    MAD

    10.4h

    05:10

    GRU

    -M-WTFS
    Search

  23. LA8032

    LATAM Airlines

    06:40

    GRU

    3.0h

    09:40

    AEP

    SMTWTFS

  24. FO5230

    Flybondi

    15:15

    AEP

    1.8h

    17:00

    SDE

    SMTWTF-

  25. UX041

    Air Europa

    23:55

    MAD

    12.7h

    07:35

    EZE

    SMTWTFS
    Search

  26. FO5230

    Flybondi

    15:15

    AEP

    1.8h

    17:00

    SDE

    SMTWTF-
Find more flights and airlines

Flight Info of Flights from Madrid to Santiago Del Estero Airport

Cheapest one-way flight price$588
Off-season for travelMarch
Peak season for travelApril

FAQs for Madrid to Santiago Del Estero Airport Flights

  • When are flight tickets from Madrid (MAD) to Santiago del Estero (SDE) the cheapest?

    Airlines adjust prices for flights from Madrid to Santiago del Estero based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Madrid (MAD) to Santiago del Estero (SDE) cost?

    According to Trip.com's data, the lowest price is around $1,470.

  • What is the transportation method from the main airport to downtown in Santiago del Estero?

    • The distance from Santiago Del Estero Airport to downtown is about 4 km. It takes about 20 minutes by taxi.

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.