Find cheap one-way flights from Cali to Des Moines starting at US$393.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

Round-trip
One way

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Cali to Des Moines?

We monitor flight fares to help you find the best deals effortlessly

Cheapest flights

From price

16 23
23 30
Apr

30 6
6 13
13 20
20 27
May

27 4
4 11
11 18
18 25
Jun

25 1
1 8

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

When are flight tickets from Cali (CLO) to Des Moines (DSM) the cheapest?

Airlines adjust prices for flights from Cali to Des Moines based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
How much do flights from Cali (CLO) to Des Moines (DSM) cost?

According to Trip.com's data, the lowest price is around $741.

How to find a cheap flight from Cali to Des Moines

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Cali to Des Moines. Book your flights at the right time and save more.

Being flexible with your dates to get the cheapest Cali to Des Moines ticket.

Tap "Date" on flight search bar to scan through the calender for Cali to Des Moines airfare over next 6 months in 2025.

Compare cheap Cali to Des Moines flight deals from over hundreds of airlines.

Our extensive search allows you to compare prices from over 500 airlines to choose the cheapest flight tickets from Cali to Des Moines.

Set up a Price Alert

By setting up a Price Alert for your Cali to Des Moines route, you can easily track the price of your airline tickets from Cali to Des Moines without manually checking every day.

Don't miss cheap Cali to Des Moines flight deals and promo codes.

You can always get the latest deals through Trip.com Deals and Promo Codes for cheap flights for cheap flights. If registering a free membership, you can receive more deals for your flights.

Book early or wait unitl the last minute.

It's always better to book early. Flight tickets tend to be the cheapest when they are first released, normally about a year before the departure date. So, check online as soon as the flights you want become available. If you miss the cheapest time, you can still find lower-priced tickets as the flight date approaches.

Search for flights on the go.

To get the best flight booking experience on the go, download Trip.com free app and search for cheap flight tickets from Cali to Des Moines to get exclusive deals for you.